Chemistry Letters

Convenient syntheses of oligoribonucleotides having 2'-5'and/or 3'-5'phosphodiester linkage.

H Ozaki, A Nakamoto, T Shimidzu

Index: Ozaki, Hiroaki; Nakamoto, Akio; Shimidzu, Takeo Chemistry Letters, 1990 , # 6 p. 959 - 962

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Abstract

Sequence-defined Oligoribonucleotides having 2′-5′ and/or 3′-5′ phosphodiester linkage have been synthesized by use of 5′-protected ribonucleoside 2′, 3′-cyclic phosphoramidite on solid support. In coupling reaction, pKa of azole as a catalyst governs the activation. The resulting 2′-5′ and/or 3′-5′ linked Oligoribonucleotides were easily separated by reversed-phase chromatography.