Design, synthesis and pharmacological evaluation of new series of naphthalenic analogues as melatoninergic (MT 1/MT 2) and serotoninergic 5-HT 2C dual ligands (I …

…, A Sabaouni, M Rami, JA Boutin, P Delagrange…

Index: Ettaoussi, Mohamed; Sabaouni, Ahmed; Rami, Marouan; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Spedding, Michael; Caignard, Daniel-Henri; Berthelot, Pascal; Yous, Said European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 310 - 323

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Citation Number: 20

Abstract

As part of our ongoing interest in developing new melatoninergic ligands bearing the same pharmacological profile as agomelatine, we focused our attention on this compound as a lead. Several chemical modifications have been performed on positions C-3 and 8 of the naphthalene ring determined as primary targets for the agomelatine metabolism. Herein we report the modulation of the positions C-3 and 7 in addition of the amide side chain ...