7-Desmethylagomelatine
Modify Date: 2025-08-24 20:39:54
7-Desmethylagomelatine structure
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Common Name | 7-Desmethylagomelatine | ||
|---|---|---|---|---|
| CAS Number | 152302-45-9 | Molecular Weight | 229.274 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 511.3±33.0 °C at 760 mmHg | |
| Molecular Formula | C14H15NO2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 263.0±25.4 °C | |
Use of 7-Desmethylagomelatine7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2]. |
| Name | N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide |
|---|---|
| Synonym | More Synonyms |
| Description | 7-Desmethyl-agomelatine is a metabolite of Agomelatine. Agomelatineis a potent agonist at melatonin receptors (MT1 and MT2), and also is an antagonist of 5-HT2C[1][2]. |
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| Related Catalog | |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 511.3±33.0 °C at 760 mmHg |
| Molecular Formula | C14H15NO2 |
| Molecular Weight | 229.274 |
| Flash Point | 263.0±25.4 °C |
| Exact Mass | 229.110275 |
| PSA | 52.82000 |
| LogP | 1.62 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.624 |
| InChIKey | UNTZQBYXDYYXIY-UHFFFAOYSA-N |
| SMILES | CC(=O)NCCc1cccc2ccc(O)cc12 |
| HS Code | 2924299090 |
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~79%
7-Desmethylagom... CAS#:152302-45-9 |
| Literature: Ettaoussi, Mohamed; Sabaouni, Ahmed; Rami, Marouan; Boutin, Jean A.; Delagrange, Philippe; Renard, Pierre; Spedding, Michael; Caignard, Daniel-Henri; Berthelot, Pascal; Yous, Said European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 310 - 323 |
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~%
7-Desmethylagom... CAS#:152302-45-9 |
| Literature: SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati Patent: WO2014/64706 A1, 2014 ; Location in patent: Page/Page column 76 ; |
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~%
7-Desmethylagom... CAS#:152302-45-9 |
| Literature: Depreux; Lesieur; Mansour; Morgan; Howell; Renard; Caignard; Pfeiffer; Delagrange; Guardiola; Yous; Demarque; Adam; Andrieux Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3231 - 3239 |
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~%
7-Desmethylagom... CAS#:152302-45-9 |
| Literature: SYMED LABS LIMITED; MOHAN RAO, Dodda; ANNA REDDY, Ambati Patent: WO2014/64706 A1, 2014 ; |
![N-[2-(7-hydroxy-1,2,3,4-tetrahydro-1-naphthyl)ethyl]acetamide structure](https://image.chemsrc.com/caspic/259/296280-78-9.png)
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Name: Activity (expressed as cAMP index) measured by the melatonin-mediated inhibition of f...
Source: ChEMBL
Target: Melatonin receptor type 1B
External Id: CHEMBL714711
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Name: Blocking the inhibitory effect of 1 nM melatonin.
Source: ChEMBL
Target: Melatonin receptor type 1B
External Id: CHEMBL714702
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Name: Negative logarithm of relative affinity (pRA) towards melatonin receptor (relative to...
Source: ChEMBL
Target: Melatonin receptor type 1B
External Id: CHEMBL715566
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Name: Binding affinity to melatonin receptor measured on ovine pars tuberalis membrane
Source: ChEMBL
Target: Melatonin receptor type 1B
External Id: CHEMBL714705
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Name: Binding affinity against chicken brain melatonin receptors using 2-[125I]iodomelatoni...
Source: ChEMBL
Target: Melatonin receptor type 1B
External Id: CHEMBL714909
|
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Name: Monophasic inhibitory concentration against melatonin receptor was measured on ovine ...
Source: ChEMBL
Target: Melatonin receptor type 1B
External Id: CHEMBL714704
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Total 6, Current Page 1 of 1
1
| 7-Demethyl-Agomelatine |
| N-[2-(7-hydroxynaphthalen-1-yl)ethyl]acetamide |
| N-[2-(7-Hydroxy-1-naphthyl)ethyl]acetamide |
| N-(2-(7-hydroxy-1-naphthyl)ethyl)acetamide |
| Agomelatine Impurity 12 |
| 7-Desmethylagomelatine |