Ru-catalyzed cyclization of terminal alkynals to cycloalkenes

JA Varela, C González-Rodríguez…

Index: Varela, Jesus A.; Gonzalez-Rodriguez, Carlos; Rubin, Silvia G.; Castedo, Luis; Saa, Carlos Journal of the American Chemical Society, 2006 , vol. 128, # 30 p. 9576 - 9577

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Citation Number: 39

Abstract

In conclusion, we have discovered a new Ru-catalyzed cyclization of terminal alkynals to give cycloalkenes. Under appropriate catalytic conditions, cycloisomerization to conjugated aldehydes may be observed. Both processes involve catalytic Ru vinylidenes. On the basis of the findings described herein, we envisage new possibilities of C−C bond formation catalyzed by transition metal vinylidenes. Research in this direction is currently underway.