Agents for the treatment of overactive detrusor. V. Synthesis and inhibitory activity on detrusor contraction of N-tert-butyl-4, 4-diphenyl-2-cyclopentenylamine.

K TAKE, K OKUMURA, K TSUBAKI…

Index: Take; Okumura; Takimoto; Kato; Ohtsuka; Shiokawa Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 2915 - 2923

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Citation Number: 8

Abstract

N-tert-Butyl-4, 4-diphenyl-2-cyclopentenylamine ((±)-3) was designed to restrict the conformation of terodiline 1 and was synthesized in a 6-step approach starting with diphenylacetaldehyde (10) or in a 4-step approach starting with 2, 2-diphenyl-4-pentenoic