Recently we reported on a series of GM1os conjugated dendrimers that showed unprecedented affinity enhancements of up to 380 000-fold beyond GM1os derivatives. 7 The strong binding was attributed to the combined use of the strong GM1os ligand and its multivalent presentation on a dendrimer with long spacer arms. 6e While these GM1os–dendrimer conjugates were very potent, the goal still remains to prepare inhibitors based on cheap bulk sugars like ...
