Pentaethylene glycol

Modify Date: 2026-07-01 20:22:45

Pentaethylene glycol structure	Common Name	Pentaethylene glycol
	CAS Number	4792-15-8	Molecular Weight	238.278
	Density	1.1±0.1 g/cm3	Boiling Point	356.1±32.0 °C at 760 mmHg
	Molecular Formula	C₁₀H₂₂O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	169.2±25.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of Pentaethylene glycol

Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

This table lists Chinese names, IUPAC names and various aliases of this chemical substance.

Name	Pentaethylene glycol
Synonym	More Synonyms

This table contains bioactivity, target information and biological‑assay experimental data of this compound.

Description	Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.

Density	1.1±0.1 g/cm3
Boiling Point	356.1±32.0 °C at 760 mmHg
Molecular Formula	C₁₀H₂₂O₆
Molecular Weight	238.278
Flash Point	169.2±25.1 °C
Exact Mass	238.141632
PSA	77.38000
LogP	-2.59
Vapour Pressure	0.0±1.8 mmHg at 25°C
Index of Refraction	1.458
InChIKey	JLFNLZLINWHATN-UHFFFAOYSA-N
SMILES	OCCOCCOCCOCCOCCO
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.

This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.

Pentaethylene glycol MSDS(Chinese)

This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RZ2670000

CHEMICAL NAME :: Pentaethylene glycol

CAS REGISTRY NUMBER :: 4792-15-8

BEILSTEIN REFERENCE NO. :: 1635593

LAST UPDATED :: 199703

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H22-O6

MOLECULAR WEIGHT :: 238.32

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 22500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),77,1987 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/m3/30D-I

TOXIC EFFECTS :: Blood - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(11),86,1987

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1300 mg/kg/26W-I

TOXIC EFFECTS :: Liver - other changes Kidney, Ureter, Bladder - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 52(12),77,1987

This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	RZ2670000
HS Code	2909499000

This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.

This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.

HS Code	2909499000
Summary	2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0%

This table lists relevant public references with title, journal and publication metadata for this compound.

Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1.

Macromol. Biosci. 15 , 1035-44, (2015)

BMP-2 and TGF-β1 released from injectable thermoresponsive hydrogels are studied in the presence and absence of branched macromolecules bearing BMP-2 or TGF-β1 affinity binding peptides. The synthesiz...

Conformation and activity of lipase B from Candida antarctica in bicontinuous microemulsions.

Colloids Surf. B Biointerfaces 131 , 108-14, (2015)

The paper at hand deals with the influence of the pH-value on the conformation and activity of the lipase B from Candida antarctica (CalB) which is incorporated in a bicontinuous microemulsion. The mi...

This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.

Pentaethylene Glycol

3,6,9,12-Tetraoxatetradecane-1,14-diol,Pentaglycol

MFCD00002878

EINECS 225-341-4

pentaethyleneglycol

2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethanol

3,6,9,12-Tetraoxatetradecane-1,14-diol

This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.

Q: What is the polar surface area (PSA) of Pentaethylene glycol?

A: Polar surface area (PSA) of Pentaethylene glycol is 77.38000.

Q: What is the molecular formula of Pentaethylene glycol?

A: Molecular formula of Pentaethylene glycol is C10H22O6.

Q: What is the boiling point of Pentaethylene glycol?

A: Boiling point of Pentaethylene glycol is 356.1±32.0 °C at 760 mmHg.

Q: What is the CAS number of Pentaethylene glycol?

A: CAS number of Pentaethylene glycol is 4792-15-8.

Q: What is the LogP of Pentaethylene glycol?

A: LogP of Pentaethylene glycol is -2.59.

Q: What English synonyms does Pentaethylene glycol have?

A: English synonyms of Pentaethylene glycol: Pentaethylene Glycol, 3,6,9,12-Tetraoxatetradecane-1,14-diol,Pentaglycol, MFCD00002878, EINECS 225-341-4, pentaethyleneglycol, 2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethanol, 3,6,9,12-Tetraoxatetradecane-1,14-diol.

Q: What is the molecular weight of Pentaethylene glycol?

A: Molecular weight of Pentaethylene glycol is 238.278.

Q: What is the InChIKey of Pentaethylene glycol?

A: InChIKey of Pentaethylene glycol is JLFNLZLINWHATN-UHFFFAOYSA-N.

Q: What is the English name of Pentaethylene glycol?

A: The English name of Pentaethylene glycol is Pentaethylene glycol.

Q: What are the uses of Pentaethylene glycol?

A: Main uses of Pentaethylene glycol: Pentaethylene glycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.

Shanghai Nianxing Industrial Co., Ltd

Dayang Chem (Hangzhou) Co., Ltd.

Zhongshan Xingrui Chemical Co. , Ltd.

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pentaethylene glycol
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pentaethylene glycol
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: Pentaethylene glycol
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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Pentaethylene glycol

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