Carbamates and ureas derived from 11-amino-6, 11-dihydrodibenzo [b, e] thiepin; Synthesis and pharmacological screening

V Valenta, M Bartošová, M Protiva

Index: Valenta; Bartosova; Protiva Collection of Czechoslovak Chemical Communications, 1980 , vol. 45, # 2 p. 517 - 528

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Citation Number: 5

Abstract

Abstract A series of N-substituted carbamates V-XIII was prepared by reactions of 6, 11- dihydrodibenzo [b, e] thiepin-11-ol (I) with carbamates H 2 NCOOR in acetic acid. Whereas the Leuckart reaction of dibenzo [b, e] thiepin-11 (6H)-one yielded 9-formamido-10- methylene-9, 10-dihydroanthracene (XVIII), a satisfactory method for preparing the amine III was found in heating the carbamate V with 2-aminoethanol to 170 C. Reactions of the ...