Regioselective Synthesis of Tetraalkynylarenes by Consecutive Dual Sonogashira Coupling Reactions of the Bis (triflate) of 4, 5??Diiodobenzene??1, 2??diol

TJ Fisher, PH Dussault

Index: Fisher, Thomas J.; Dussault, Patrick H. European Journal of Organic Chemistry, 2012 , # 14 p. 2831 - 2836

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Abstract

Abstract The regioselective synthesis of nonsymmetric tetraalkynylarenes has been readily achieved through consecutive sets of Sonagashira cross-coupling reactions of the bis (triflate) derivative of 4, 5-diiodobenzene-1, 2-diol. The initial coupling reactions proceeded with nearly complete selectivity for the reaction at the Ar–I linkages. Subsequent coupling reactions at the Ar–OTf linkages were efficiently conducted. The tetraalkynylarene ...