Synthesis and performance of acyloxy-diene-Fe (CO) 3 complexes with variable chain lengths as enzyme-triggered carbon monoxide-releasing molecules

…, M Guttentag, R Alberto, JM Neudörfl…

Index: Romanski, Steffen; Kraus, Birgit; Guttentag, Miguel; Schlundt, Waldemar; Ruecker, Hannelore; Adler, Andreas; Neudoerfl, Joerg-Martin; Alberto, Roger; Amslinger, Sabine; Schmalz, Hans-Guenther Dalton Transactions, 2012 , vol. 41, # 45 p. 13862 - 13875

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Citation Number: 20

Abstract

Novel η4-acyloxy-cyclohexadiene-Fe (CO) 3 complexes (with variable length of the acyloxy chain) were synthesized as potential enzyme-triggered carbon monoxide (CO)-releasing molecules (ET-CORMs). The molecular structure of two complexes was additionally confirmed by X-ray crystallography. The enzyme-triggered CO-releasing activity of the compounds was assessed under physiological conditions (37° C, 0.1 M phosphate buffer, ...