Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates

…, AJ Cox, RM Gow, Y Zhang, RE Gilbert, H Krum…

Index: Zammit, Steven C.; Cox, Alison J.; Gow, Renae M.; Zhang, Yuan; Gilbert, Richard E.; Krum, Henry; Kelly, Darren J.; Williams, Spencer J. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 7003 - 7006

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Citation Number: 31

Abstract

Tranilast is an anti-inflammatory drug in use for asthma and atopic dermatitis. In studies over the last decade it has been revealed that tranilast can reduce fibrosis occurring in the kidney during diabetes, thereby delaying and/or preventing kidney dysfunction. We report a structure–activity study aimed at optimizing the antifibrotic activity of tranilast. A series of cinnamoyl anthranilates were prepared and assessed for their ability to prevent TGF-β- ...

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Nitrone dipolar cycloaddition routes to piperidines and indo...

[Davison, Edwin C.; Fox, Martin E.; Holmes, Andrew B.; Roughley, Stephen D.; Smith, Catherine J.; Williams, Geoffrey M.; Davies, John E.; Raithby, Paul R.; Adams, Joseph P.; Forbes, Ian T.; Press, Neil J.; Thompson, Mervyn J. Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 12 p. 1494 - 1514]