e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Highly Efficient Route to Functionalized Tetrahydrocarbazoles Using a Tandem Cross??Metathesis/Intramolecular??Hydroarylation Sequence

…, FG Zhang, YQ Zou, YC Guo, WJ Xiao

Index: An, Xiao-Lei; Chen, Jia-Rong; Li, Chang-Feng; Zhang, Fu-Gen; Zou, You-Quan; Guo, Ying-Cen; Xiao, Wen-Jing Chemistry - An Asian Journal, 2010 , vol. 5, # 10 p. 2258 - 2265

Full Text: HTML

Citation Number: 32

Abstract

Abstract The scope of the novel ruthenium-catalyzed tandem cross-metathesis/ intramolecular-hydroarylation sequence is described. This methodology offers a practical and efficient synthesis of structurally diverse and complex tetrahydrocarbazoles in good to excellent yields (up to 98%). Moreover, preliminary efforts towards the development of an enantioselective version of the current process by sequential catalysis with ruthenium ...

1-(2-Methoxyphenyl)ethanone Structure

1-(2-Methoxyphe...

~%

1-(2-methoxyphenyl)prop-2-en-1-one Structure

1-(2-methoxyphe...

Formaldehyde Structure

N/A Structure

~52%

1-(2-methoxyphenyl)prop-2-en-1-one Structure

1-(2-methoxyphe...

o-methoxy phenacylbromide Structure

o-methoxy phena...

~%

1-(2-methoxyphenyl)prop-2-en-1-one Structure

1-(2-methoxyphe...

Ortho-Hydroxyacetophenone Structure

Ortho-Hydroxyac...

~%

1-(2-methoxyphenyl)prop-2-en-1-one Structure

1-(2-methoxyphe...

(2-(2-methoxyphenyl)-2-oxoethyl)triphenylphosphonium bromide Structure

(2-(2-methoxyph...

~%

1-(2-methoxyphenyl)prop-2-en-1-one Structure

1-(2-methoxyphe...

4'-Fluoroacetophenone Structure

4'-Fluoroacetop...

~%

1-(4-fluorophenyl)prop-2-en-1-one Structure

1-(4-fluorophen...

p-Fluorophenacyl bromide Structure

p-Fluorophenacy...

~%

1-(4-fluorophenyl)prop-2-en-1-one Structure

1-(4-fluorophen...

Formaldehyde Structure

1-(4-fluorophenyl)-2-(triphenyl-λ5phosphanylidene)ethanone Structure

1-(4-fluorophen...

~29%

1-(4-fluorophenyl)prop-2-en-1-one Structure

1-(4-fluorophen...

[2-(4-fluorophenyl)-2-oxoethyl]-triphenylphosphanium,bromide Structure

[2-(4-fluorophe...

~%

1-(4-fluorophenyl)prop-2-en-1-one Structure

1-(4-fluorophen...

Formaldehyde Structure

1-(4-methoxyphenyl)-2-(triphenyl-λ-phosphoranylidene)ethanone Structure

1-(4-methoxyphe...

~87%

1-(4-methoxyphenyl)prop-2-en-1-one Structure

1-(4-methoxyphe...

PTP inhibitor 1 Structure

PTP inhibitor 1

~%

1-(4-methoxyphenyl)prop-2-en-1-one Structure

1-(4-methoxyphe...

(2-(4-methoxyphenyl)-2-oxoethyl)triphenylphosphonium bromide Structure

(2-(4-methoxyph...

~%

1-(4-methoxyphenyl)prop-2-en-1-one Structure

1-(4-methoxyphe...

Formaldehyde Structure

1-(3-methoxyphenyl)-2-(triphenyl-λ5-phosphanylidene)ethanone Structure

1-(3-methoxyphe...

~90%

1-(3-methoxyphenyl)prop-2-en-1-one Structure

1-(3-methoxyphe...

(2-(3-methoxyphenyl)-2-oxoethyl)triphenylphosphonium bromide Structure

(2-(3-methoxyph...

~%

1-(3-methoxyphenyl)prop-2-en-1-one Structure

1-(3-methoxyphe...

2-Bromo-1-(3-methoxyphenyl)ethanone Structure

2-Bromo-1-(3-me...

~%

1-(3-methoxyphenyl)prop-2-en-1-one Structure

1-(3-methoxyphe...

(2-(3-methoxyphenyl)-2-oxoethyl)triphenylphosphonium bromide Structure

(2-(3-methoxyph...

~%

1-(3-methoxyphenyl)-2-(triphenyl-λ5-phosphanylidene)ethanone Structure

1-(3-methoxyphe...

2-Bromo-1-(3-methoxyphenyl)ethanone Structure

2-Bromo-1-(3-me...

Triphenylphosphine Structure

Triphenylphosphine

~%

1-(3-methoxyphenyl)-2-(triphenyl-λ5-phosphanylidene)ethanone Structure

1-(3-methoxyphe...

1-(4-Chlorophenyl)ethanone Structure

1-(4-Chlorophen...

~%

1-(4-chlorophenyl)-2-triphenylphosphoranylidene-ethanone Structure

1-(4-chlorophen...

1-(4-Bromophenyl)ethanone Structure

1-(4-Bromopheny...

~%

Phosphonium,[2-(4-bromophenyl)-2-oxoethyl]triphenyl-, bromide (1:1) Structure

Phosphonium,[2-...

2,4′-dibromoacetophenone Structure

2,4′-dibromoace...

~%

Ethanone,1-(4-bromophenyl)-2-(triphenylphosphoranylidene)- Structure

Ethanone,1-(4-b...

1-(4-Bromophenyl)ethanone Structure

1-(4-Bromopheny...

~%

Ethanone,1-(4-bromophenyl)-2-(triphenylphosphoranylidene)- Structure

Ethanone,1-(4-b...

Formaldehyde Structure

1-(4-methylphenyl)-2-(triphenylphosphoranylidene)ethanone Structure

1-(4-methylphen...

~94%

1-(4-methylphenyl)prop-2-en-1-one Structure

1-(4-methylphen...

4'-Methylacetophenone Structure

4'-Methylacetop...

~%

1-(4-methylphenyl)prop-2-en-1-one Structure

1-(4-methylphen...

2-bromo-4'-methylacetophenone Structure

2-bromo-4'-meth...

~%

1-(4-methylphenyl)prop-2-en-1-one Structure

1-(4-methylphen...

(4'-methylphenacyl)triphenylphosphonium bromide Structure

(4'-methylphena...

~%

1-(4-methylphenyl)prop-2-en-1-one Structure

1-(4-methylphen...

Formaldehyde Structure

(Phenylcarbonylmethylene)triphenylphosphorane Structure

(Phenylcarbonyl...

~93%

Acrylophenone Structure

m-Bromoacetophenone Structure

m-Bromoacetophenone

~%

1-(3-bromophenyl)-2-(triphenyl-λ5-phosphanylidene)ethanone Structure

1-(3-bromopheny...

2-Bromo-1-(3-bromophenyl)ethanone Structure

2-Bromo-1-(3-br...

~%

1-(3-bromophenyl)-2-(triphenyl-λ5-phosphanylidene)ethanone Structure

1-(3-bromopheny...

Phenacyl Bromide Structure

Phenacyl Bromide

~%

1-(2-bromophenyl)prop-2-en-1-one Structure

1-(2-bromopheny...

2-Bromophenacyl bromide Structure

2-Bromophenacyl...

~%

1-(2-bromophenyl)prop-2-en-1-one Structure

1-(2-bromopheny...

Formaldehyde Structure

N/A Structure

~40%

1-(2-bromophenyl)prop-2-en-1-one Structure

1-(2-bromopheny...

Synthesis of (±)-puraquinonic acid: an inducer of cell diffe...

[Carter, Rachel H.; Garson, Mary J.; Hill, Robert A.; Staunton, James; Sunter, David C. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981 , p. 471 - 479]