Novel Benzo [d] imidazole-2 (3H)-thiones as Potent Inhibitors of the. ALPHA.-Melanocyte Stimulating Hormone Induced Melanogenesis in Melanoma B16 Cells

JH Lee, P Thanigaimalai, KC Lee, SC Bang…

Index: Lee, Jee-Hyun; Thanigaimalai, Pillaiyar; Lee, Ki-Cheul; Bang, Seong-Cheol; Kim, Min-Seok; Sharma, Vinay Kumar; Yun, Cheong-Yong; Roh, Eunmiri; Kim, Youngsoo; Jung, Sang-Hun Chemical and Pharmaceutical Bulletin, 2010 , vol. 58, # 7 p. 918 - 921

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Citation Number: 4

Abstract

In order to determine the optimum size of heterocycle of lead compound 1 (6-methyl-3- phenethyl-3, 4-dihydro-1H-quinoline-2-thione; IC 50= 0.8 μM) for inhibition of melanogenesis, we have synthesized and evaluated some benzimdazole-2 (3H)-thiones ...