Acyclic analogs of 2'-deoxynucleosides related to 9-[(1, 3-dihydroxy-2-propoxy) methyl] guanine as potential antiviral agents

…, DF Smee, TR Matthews, JPH Verheyden

Index: Martin; Jeffrey; McGee; Tippie; Smee; Matthews; Verheyden Journal of Medicinal Chemistry, 1985 , vol. 28, # 3 p. 358 - 362

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Citation Number: 33

Abstract

A series of acyclic analogues of 2~-deoxynucleosides related in structure to 9-[(1, 3- dihydroxy-2-propoxy) methyl] guanine (DHPG, 1) have been synthesized and evaluated for antiviral activity against herpes simplex virus type 1 (F strain). Additionally, the ability of these analogues to function as substrates for the virus-specified thymidine kinase was examined. Phosphorylation by this kinase is essential for antiviral activity. Although the ...