Tetrahedron

A new, direct, and efficient synthesis of benzonaphthyridin-5-ones

T Cailly, F Fabis, S Rault

Index: Cailly, Thomas; Fabis, Frederic; Rault, Sylvain Tetrahedron, 2006 , vol. 62, # 25 p. 5862 - 5867

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Citation Number: 19

Abstract

Microwave-assisted Suzuki cross-coupling reaction of 2-fluorophenylboronic acid with all orthochlorocyanopyridine isomers allowed the rapid syntheses of key intermediates for anionic ring closure, which was performed using potassium hydroxide under microwave irradiation to give benzonaphthyridin-5-ones in high yields.