Novel schistosomicides. S-2-{[2-(2-Thiazolylcarbamoyl) ethyl] amino} ethyl hydrogen thiosulfate and related compounds

RD Westland, LM Werbel, JR Dice…

Index: Westland,R.D. et al. Journal of Medicinal Chemistry, 1971 , vol. 14, # 10 p. 916 - 920

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Citation Number: 9

Abstract

8-2-{[2-(2-Thiazolylcarbamoy1) et~ hyl] amino) ethyl hydrogen thiosulfate (3a), prepared by alkylation of S-2-aminoethyl hydrogen thiosulfat, e with 3-chloro-AY-2-thiazolylpropionamide (1) has been found to be highly effec-tive against'infections of Schistosoma mansoni in mice and monkeys. The thiol, 3-[(2-mercaptoethyl) amino]-~ I'-2-thiazolylpropionamide~ HCl (S), prepared from~\ r-2-thiazolyl-l-aziridinepropionamide (5a) and H2S, had about the same ...