Efficient Copper??Catalyzed Cross??Coupling Reaction of Alkynes with Aryl Iodides

CH Lin, YJ Wang, CF Lee

Index: Lin, Che-Hung; Wang, Yu-Jen; Lee, Chin-Fa European Journal of Organic Chemistry, 2010 , # 23 p. 4368 - 4371

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Citation Number: 22

Abstract

Abstract A copper-catalyzed cross-coupling reaction of alkynes with aryl iodides is described. The system tolerates a broad range of functional groups and enables the use of sterically demanding substrates with only 1.0–2.5 mol-% of Cu 2 O and 1.0–2.5 mol-% of xantphos as the catalyst.