Substitution of a nonbridging oxygen atom of a phosphate diester internucleotide linkage is one of the conventional methods used to confer additional properties and functions on oligonucleotides. The resultant P-modified oligonucleotide analogues possess the additional properties and functions (eg, stability to nucleases, cell membrane permeability) while still retain those inherent to the parent oligonucleotides (eg, solubility in water, ability ...
