Selective binding of mannose-encapsulated gold nanoparticles to type 1 pili in Escherichia coli

…, CY Yang, CL Chen, GF Chen, CC Chen…

Index: Lin, Chun-Cheng; Yeh, Yi-Chun; Yang, Chan-Yi; Chen, Chan-Long; Chen, Gee-Fong; Chen, Chia-Chun; Wu, Yi-Chun Journal of the American Chemical Society, 2002 , vol. 124, # 14 p. 3508 - 3509

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Citation Number: 277

Abstract

The synthesis, characterization and biological application of mannose encapsulated gold nanoparticles (m-AuNP) are reported. m-AuNP is well dispersed and very stable without aggregation in the media of broad ion strength and pH ranges. The selective binding of m- AuNP to the mannose adhesin FimH of bacterial type 1 pili is demonstrated using transmission electron microscopy. The competition assay with free mannose suggests that ...