e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Chemical and Pharmaceutical Bulletin

Synthesis of imidazo (1, 5-a) pyrimidines.

片桐信弥，厚海修吾，加藤鐵三

Index: Katagiri, Nobuya; Atsuumi, Shugo; Kato, Tetsuzo Chemical & Pharmaceutical Bulletin, 1983 , vol. 31, # 8 p. 2540 - 2551

Full Text: HTML

Citation Number: 0

Abstract

... BulL} 31(8)2540vv2551(1983) Synthesis of Imidaz0[l,5-a]pyrimidines1) NOBUYA KATAGIRI, SHUGO ATSUUMI, and TETSUZO KAT0* Pharmaceutical ... These chemical reactions also support the rearrangement of 7 to 8. POC13 [ (R1:H,R2:CHMez) | C1 C] R2 4 5 6 /\ 3a—i ...

N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-2-phenylethyl)benzamide Structure

N-(1-(4-methyl-...

~8%

8-benzyl-4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-4-chlo...

8-benzyl-2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-2-chlo...

N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-2-phenylethyl)benzamide Structure

N-(1-(4-methyl-...

~0%

N-[1-(4-chloro-6-methylpyrimidin-2-yl)-2-phenylethyl]benzamide Structure

N-[1-(4-chloro-...

8-benzyl-4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-4-chlo...

8-benzyl-2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-2-chlo...

Piperidine Structure

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

~75%

4-methyl-6-phenyl-2-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

4-methyl-6-phen...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~%

4-methyl-6-phenyl-2-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

4-methyl-6-phen...

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

~75%

4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-methyl-6-phen...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~%

4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-methyl-6-phen...

2-chloro-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6,8-...

~63%

4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4,6,8-trimethyl...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4,6,8-trimethyl...

morpholine Structure

2-chloro-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6,8-...

~59%

4-(4,6,8-trimethylimidazo[1,5-a]pyrimidin-2-yl)morpholine Structure

4-(4,6,8-trimet...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

4-(4,6,8-trimethylimidazo[1,5-a]pyrimidin-2-yl)morpholine Structure

4-(4,6,8-trimet...

N-(3-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)butyl)acetamide Structure

N-(3-methyl-1-(...

~16%

4-chloro-2,6-dimethyl-8-(2-methylpropyl)imidazo[1,5-a]pyrimidine Structure

4-chloro-2,6-di...

2-chloro-4,6-dimethyl-8-(2-methylpropyl)imidazo[1,5-a]pyrimidine Structure

2-chloro-4,6-di...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~72%

2-chloro-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6,8-...

4-chloro-2,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,6,8-...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(6-methyl-...

~82%

4-chloro-2,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,8-di...

2-chloro-4,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,8-di...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(6-methyl-...

~18%

4-chloro-2,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,8-di...

2-chloro-4,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,8-di...

N-[1-(4-chloro-6-methylpyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(4-chloro-...

Piperidine Structure

2-chloro-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6,8-...

~77%

4,6,8-trimethyl-2-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

4,6,8-trimethyl...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

4,6,8-trimethyl-2-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

4,6,8-trimethyl...

morpholine Structure

2-chloro-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6-di...

~55%

4-(4,6-dimethylimidazo[1,5-a]pyrimidin-2-yl)morpholine Structure

4-(4,6-dimethyl...

2,6-dimethyl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2,6-dimethyl-1H...

~%

4-(4,6-dimethylimidazo[1,5-a]pyrimidin-2-yl)morpholine Structure

4-(4,6-dimethyl...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]acetamide Structure

N-[(6-methyl-4-...

~%

4-(4,6-dimethylimidazo[1,5-a]pyrimidin-2-yl)morpholine Structure

4-(4,6-dimethyl...

morpholine Structure

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

~79%

4-(4-methyl-6-phenylimidazo[1,5-a]pyrimidin-2-yl)morpholine Structure

4-(4-methyl-6-p...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~%

4-(4-methyl-6-phenylimidazo[1,5-a]pyrimidin-2-yl)morpholine Structure

4-(4-methyl-6-p...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~36%

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]benzamide Structure

N-[(4-chloro-6-...

N-[(S)-1-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-2-phenyl-ethyl]-acetamide Structure

N-[(S)-1-(4-Met...

~51%

8-benzyl-2-chloro-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

8-benzyl-2-chlo...

8-benzyl-4-chloro-2,6-dimethylimidazo[1,5-a]pyrimidine Structure

8-benzyl-4-chlo...

2-[(isobutyrylamino)methyl]-6-methylpyrimidin-4(3H)-one Structure

2-[(isobutyryla...

~%

4-methoxy-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-methoxy-2-met...

2-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2-methyl-6-prop...

~%

4-methoxy-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-methoxy-2-met...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

~%

4-methoxy-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-methoxy-2-met...

Sodium Methylate Structure

Sodium Methylate

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

~34%

4-methoxy-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-methoxy-2-met...

2-chloro-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6-di...

~47%

4,6-dimethyl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4,6-dimethyl-1H...

2,6-dimethyl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2,6-dimethyl-1H...

~%

4,6-dimethyl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4,6-dimethyl-1H...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]acetamide Structure

N-[(6-methyl-4-...

~%

4,6-dimethyl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4,6-dimethyl-1H...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(6-methyl-...

~76%

4-chloro-2,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,8-di...

2-chloro-4,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,8-di...

N-[1-(4-chloro-6-methylpyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(4-chloro-...

Sodium Methylate Structure

Sodium Methylate

4-chloro-2,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,6,8-...

~73%

4-methoxy-2,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4-methoxy-2,6,8...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

4-methoxy-2,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4-methoxy-2,6,8...

Sodium Methylate Structure

Sodium Methylate

2-chloro-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6-di...

~74%

2-methoxy-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4,6-d...

2,6-dimethyl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2,6-dimethyl-1H...

~%

2-methoxy-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4,6-d...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]acetamide Structure

N-[(6-methyl-4-...

~%

2-methoxy-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4,6-d...

2-[(isobutyrylamino)methyl]-6-methylpyrimidin-4(3H)-one Structure

2-[(isobutyryla...

~%

2-methoxy-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4-met...

Sodium Methylate Structure

Sodium Methylate

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

~80%

2-methoxy-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4-met...

2-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2-methyl-6-prop...

~%

2-methoxy-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4-met...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

~%

2-methoxy-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4-met...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

~%

2-methoxy-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4-met...

N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-2-phenylethyl)benzamide Structure

N-(1-(4-methyl-...

~73%

8-benzyl-4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-4-chlo...

8-benzyl-2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-2-chlo...

N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-2-phenylethyl)benzamide Structure

N-(1-(4-methyl-...

~10%

N-[1-(4-chloro-6-methylpyrimidin-2-yl)-2-phenylethyl]benzamide Structure

N-[1-(4-chloro-...

8-benzyl-4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-4-chlo...

8-benzyl-2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-2-chlo...

N-(1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)-2-phenylethyl)benzamide Structure

N-(1-(4-methyl-...

~66%

N-[1-(4-chloro-6-methylpyrimidin-2-yl)-2-phenylethyl]benzamide Structure

N-[1-(4-chloro-...

8-benzyl-4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-4-chlo...

8-benzyl-2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

8-benzyl-2-chlo...

N-(3-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)butyl)benzamide Structure

N-(3-methyl-1-(...

~73%

4-Chloro-8-isobutyl-2-methyl-6-phenyl-imidazo[1,5-a]pyrimidine Structure

4-Chloro-8-isob...

2-Chloro-8-isobutyl-4-methyl-6-phenyl-imidazo[1,5-a]pyrimidine Structure

2-Chloro-8-isob...

N-[1-(4-chloro-6-methylpyrimidin-2-yl)-3-methylbutyl]benzamide Structure

N-[1-(4-chloro-...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~3%

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]benzamide Structure

N-[(4-chloro-6-...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~1%

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

~28%

4-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4-methyl-6-prop...

2-[(isobutyrylamino)methyl]-6-methylpyrimidin-4(3H)-one Structure

2-[(isobutyryla...

~%

4-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4-methyl-6-prop...

N-(3-methyl-1-(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)butyl)acetamide Structure

N-(3-methyl-1-(...

~76%

4-chloro-2,6-dimethyl-8-(2-methylpropyl)imidazo[1,5-a]pyrimidine Structure

4-chloro-2,6-di...

2-chloro-4,6-dimethyl-8-(2-methylpropyl)imidazo[1,5-a]pyrimidine Structure

2-chloro-4,6-di...

2-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2-methyl-6-prop...

~49%

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

~11%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

2-[(isobutyrylamino)methyl]-6-methylpyrimidin-4(3H)-one Structure

2-[(isobutyryla...

~4%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

2-[(isobutyrylamino)methyl]-6-methylpyrimidin-4(3H)-one Structure

2-[(isobutyryla...

~%

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]acetamide Structure

N-[(6-methyl-4-...

~73%

2-chloro-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6-di...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~17%

2-chloro-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6,8-...

4-chloro-2,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,6,8-...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(6-methyl-...

~9%

4-chloro-2,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,8-di...

2-chloro-4,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,8-di...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(6-methyl-...

~3%

4-chloro-2,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,8-di...

2-chloro-4,8-dimethyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,8-di...

N-[1-(4-chloro-6-methylpyrimidin-2-yl)ethyl]benzamide Structure

N-[1-(4-chloro-...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

~63%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

2-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2-methyl-6-prop...

~69%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

~87%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

2-[(isobutyrylamino)methyl]-6-methylpyrimidin-4(3H)-one Structure

2-[(isobutyryla...

~37%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

~%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~34%

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]benzamide Structure

N-[(4-chloro-6-...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~73%

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

Sodium Methylate Structure

Sodium Methylate

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

~74%

2-methoxy-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4-met...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~%

2-methoxy-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4-met...

Sodium Methylate Structure

Sodium Methylate

2-chloro-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6,8-...

~86%

2-methoxy-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4,6,8...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

2-methoxy-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-methoxy-4,6,8...

2-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2-methyl-6-prop...

~%

4-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4-methyl-6-prop...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

~%

4-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4-methyl-6-prop...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...

~%

4-methyl-6-propan-2-yl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4-methyl-6-prop...

Piperidine Structure

4-chloro-2,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,6,8-...

~90%

2,6,8-trimethyl-4-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

2,6,8-trimethyl...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

2,6,8-trimethyl-4-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

2,6,8-trimethyl...

morpholine Structure

4-chloro-2,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

4-chloro-2,6,8-...

~87%

4-(2,6,8-trimethylimidazo[1,5-a]pyrimidin-4-yl)morpholine Structure

4-(2,6,8-trimet...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

4-(2,6,8-trimethylimidazo[1,5-a]pyrimidin-4-yl)morpholine Structure

4-(2,6,8-trimet...

Piperidine Structure

2-chloro-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6-di...

~67%

4,6-dimethyl-2-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

4,6-dimethyl-2-...

2,6-dimethyl-1H-imidazo[1,5-a]pyrimidin-4-one Structure

2,6-dimethyl-1H...

~%

4,6-dimethyl-2-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

4,6-dimethyl-2-...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]acetamide Structure

N-[(6-methyl-4-...

~%

4,6-dimethyl-2-piperidin-1-ylimidazo[1,5-a]pyrimidine Structure

4,6-dimethyl-2-...

2-chloro-4-methyl-6-phenylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

~48%

4-methyl-6-phenyl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4-methyl-6-phen...

N-[(6-methyl-4-oxo-1H-pyrimidin-2-yl)methyl]benzamide Structure

N-[(6-methyl-4-...

~%

4-methyl-6-phenyl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4-methyl-6-phen...

2-chloro-4,6,8-trimethylimidazo[1,5-a]pyrimidine Structure

2-chloro-4,6,8-...

~65%

4,6,8-trimethyl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4,6,8-trimethyl...

N-[1-(6-methyl-4-oxo-1H-pyrimidin-2-yl)ethyl]acetamide Structure

N-[1-(6-methyl-...

~%

4,6,8-trimethyl-1H-imidazo[1,5-a]pyrimidin-2-one Structure

4,6,8-trimethyl...

N-[(S)-1-(4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-yl)-2-phenyl-ethyl]-acetamide Structure

N-[(S)-1-(4-Met...

~16%

8-benzyl-2-chloro-4,6-dimethylimidazo[1,5-a]pyrimidine Structure

8-benzyl-2-chlo...

8-benzyl-4-chloro-2,6-dimethylimidazo[1,5-a]pyrimidine Structure

8-benzyl-4-chlo...

2-[(isobutyrylamino)methyl]-6-methylpyrimidin-4(3H)-one Structure

2-[(isobutyryla...

~31%

2-chloro-4-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

2-chloro-4-meth...

4-chloro-2-methyl-6-propan-2-ylimidazo[1,5-a]pyrimidine Structure

4-chloro-2-meth...

N-[(4-chloro-6-methylpyrimidin-2-yl)methyl]-2-methylpropanamide Structure

N-[(4-chloro-6-...