Ruthenium-catalyzed oxidative transformation of alkenes to. alpha.-ketols with peracetic acid. Simple synthesis of cortisone acetate

S Murahashi, T Saito, H Hanaoka…

Index: Murahashi, Shun-Ichi; Saito, Takao; Hanaoka, Hidenori; Murakami, Yoshihide; Naota, Takeshi; et al. Journal of Organic Chemistry, 1993 , vol. 58, # 11 p. 2929 - 2930

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Citation Number: 70

Abstract

Summary: The reactions of alkenes with peracetic acid in the presence of RuCl3 catalyst gave the corresponding a-ketols, which are important building unite for synthesis of biological active compounds, such as cortisone acetate. a-Ketols are important synthetic intermediates and partial structures of various biologically active compounds such as cortisone acetate (1) l and adriamycin acetate (2L2

~30%

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