Pyridinethiones. VIII. The aldol and wittig condensations of 3??formyl??2 (1H)??pyridones,??thiones and??selones. Preparation of new cyanopyridones

…, J Becher, I Winckelmann

Index: Michael, Maged Aziz; Becher, Jan; Winckelmann, Ib Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1651 - 1656

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Citation Number: 6

Abstract

Abstract Condensations of 1-substituted-3-formyl-2 (1H)-pyridones,-thiones and-selones with methyl ketones such as acetophenone give the corresponding chalcones in high yields. Geometry at the vinyl hydrogens is E. These chalcones can be cyclized with ethyl cyanoacetate in the presence of ammonium acetate to form new 3-cyano-2 (1H)-pyridones. An effective “one-pot” preparation is worked out and an intermediate from the cyclization ...