Convenient synthesis of 8-amino-2′-deoxyadenosine

M Frieden, A Aviñó, R Eritja

Index: Frieden, Miriam; Avino, Anna; Eritja, Ramon Nucleosides, Nucleotides and Nucleic Acids, 2003 , vol. 22, # 2 p. 193 - 202

Full Text: HTML

Citation Number: 9

Abstract

Abstract We studied the behaviour of 8-azido-2′-deoxyadenosine and 8-bromo-2′- deoxyadenosine in aqueous solutions of ammonia and primary and secondary amines. Unexpectedly, 8-Azido-2′-deoxyadenosine is converted to 8-amino-2′-deoxyadenosine in excellent yields. The use of this reaction for the preparation of 8-aminoadenine derivatives needed for the preparation of oligonucleotides carrying 8-aminoadenine is discussed.