e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI

H Kitagawa, K Kumura, S Takahata, M Iida…

Index: Kitagawa, Hideo; Kumura, Ko; Takahata, Sho; Iida, Maiko; Atsumi, Kunio Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1106 - 1116

Full Text: HTML

Citation Number: 45

Abstract

Bacterial FAS provides essential fatty acids for use in the assembly of key cellular components. Among them, FabI is an enoyl-ACP reductase which catalyzes the final and rate-limiting step of bacterial FAS. It is a potential target for selective antibacterial action, because it shows low overall sequence homology with mammalian enzymes. Until today, various compounds have been reported as inhibitors of bacterial FabI-inhibitory ...

benzyl 3-((2-chlorophenyl)(hydroxy)methyl)-2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 3-((2-ch...

~%

3-[(2-chlorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2-chlorophe...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-[(2-chlorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2-chlorophe...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-[(2-chlorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2-chlorophe...

benzyl 3-((2,6-dimethylphenyl)(hydroxy)methyl)-2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 3-((2,6-...

~%

3-[(2,6-dimethylphenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2,6-dimethy...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-[(2,6-dimethylphenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2,6-dimethy...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-[(2,6-dimethylphenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2,6-dimethy...

benzyl 3-(cyclohexyl(hydroxy)methyl)-2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 3-(cyclo...

~%

3-(cyclohexylmethyl)-2-methyl-1H-pyridin-4-one Structure

3-(cyclohexylme...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-(cyclohexylmethyl)-2-methyl-1H-pyridin-4-one Structure

3-(cyclohexylme...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-(cyclohexylmethyl)-2-methyl-1H-pyridin-4-one Structure

3-(cyclohexylme...

1-benzyl-2-methyl-4-pyridon-3-yl trifluoromethanesulfonate Structure

1-benzyl-2-meth...

(6-Butyl-5-decen-5-yl)-λ2-stannane Structure

(6-Butyl-5-dece...

~61%

1-benzyl-3-ethenyl-2-methylpyridin-4-one Structure

1-benzyl-3-ethe...

Maltol Structure

~%

1-benzyl-3-ethenyl-2-methylpyridin-4-one Structure

1-benzyl-3-ethe...

Hnbp Structure

~%

1-benzyl-3-ethenyl-2-methylpyridin-4-one Structure

1-benzyl-3-ethe...

Benzylamine Structure

~%

1-benzyl-3-ethenyl-2-methylpyridin-4-one Structure

1-benzyl-3-ethe...

benzyl 3-((2,6-dichlorophenyl)((methylsulfonyl)oxy)methyl)-2-ethyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 3-((2,6-...

~%

3-[(2,6-dichlorophenyl)methyl]-2-ethyl-1H-pyridin-4-one Structure

3-[(2,6-dichlor...

BENZYL 2-ETHYL-4-OXO-3,4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE Structure

BENZYL 2-ETHYL-...

~%

3-[(2,6-dichlorophenyl)methyl]-2-ethyl-1H-pyridin-4-one Structure

3-[(2,6-dichlor...

benzyl 3-((2,6-dichlorophenyl)(hydroxy)methyl)-2-ethyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 3-((2,6-...

~%

3-[(2,6-dichlorophenyl)methyl]-2-ethyl-1H-pyridin-4-one Structure

3-[(2,6-dichlor...

2,6-Dichlorobenzaldehyde Structure

2,6-Dichloroben...

~%

3-[(2,6-dichlorophenyl)methyl]-2-ethyl-1H-pyridin-4-one Structure

3-[(2,6-dichlor...

benzyl 2-butyl-3-((2,6-dichlorophenyl)((methylsulfonyl)oxy)methyl)-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 2-butyl-...

~%

2-butyl-3-[(2,6-dichlorophenyl)methyl]-1H-pyridin-4-one Structure

2-butyl-3-[(2,6...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

2-butyl-3-[(2,6-dichlorophenyl)methyl]-1H-pyridin-4-one Structure

2-butyl-3-[(2,6...

benzyl 2-butyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 2-butyl-...

~%

2-butyl-3-[(2,6-dichlorophenyl)methyl]-1H-pyridin-4-one Structure

2-butyl-3-[(2,6...

Structure

~%

2-butyl-3-[(2,6-dichlorophenyl)methyl]-1H-pyridin-4-one Structure

2-butyl-3-[(2,6...

2,6-Dichlorobenzaldehyde Structure

2,6-Dichloroben...

~%

2-butyl-3-[(2,6-dichlorophenyl)methyl]-1H-pyridin-4-one Structure

2-butyl-3-[(2,6...

3-(2,6-dichlorobenzyl)-2-methylpyridin-4(1H)-one Structure

3-(2,6-dichloro...

(Bromomethyl)cyclohexane Structure

(Bromomethyl)cy...

~71%

4-(cyclohexylmethoxy)-3-[(2,6-dichlorophenyl)methyl]-2-methylpyridine Structure

4-(cyclohexylme...

1-benzyloxycarbonyl-3-((2,6-dichlorophenyl)hydroxymethyl)-2,3-dihydro-2-methylpyridin-4(1H)-one Structure

1-benzyloxycarb...

~%

4-(cyclohexylmethoxy)-3-[(2,6-dichlorophenyl)methyl]-2-methylpyridine Structure

4-(cyclohexylme...

1-benzyloxycarbonyl-3-((2,6-dichlorophenyl)(methylsulfonyloxy)methyl)-2,3-dihydro-2-methylpyridin-4(1H)-one Structure

1-benzyloxycarb...

~%

4-(cyclohexylmethoxy)-3-[(2,6-dichlorophenyl)methyl]-2-methylpyridine Structure

4-(cyclohexylme...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

4-(cyclohexylmethoxy)-3-[(2,6-dichlorophenyl)methyl]-2-methylpyridine Structure

4-(cyclohexylme...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

4-(cyclohexylmethoxy)-3-[(2,6-dichlorophenyl)methyl]-2-methylpyridine Structure

4-(cyclohexylme...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-[(2,4-dichlorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2,4-dichlor...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-[(2,4-dichlorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2,4-dichlor...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

2-methyl-3-[(2,4,6-trichlorophenyl)methyl]-1H-pyridin-4-one Structure

2-methyl-3-[(2,...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

2-methyl-3-[(2,4,6-trichlorophenyl)methyl]-1H-pyridin-4-one Structure

2-methyl-3-[(2,...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-[(2-chloro-6-fluorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2-chloro-6-...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-[(2-chloro-6-fluorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2-chloro-6-...

1-benzyloxycarbonyl-3-butylidene-2,3-dihydro-2-methyl-4-pyridone Structure

1-benzyloxycarb...

~91%

3-butyl-2-methyl-1H-pyridin-4-one Structure

3-butyl-2-methy...

benzyl 3-(1-hydroxybutyl)-2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 3-(1-hyd...

~%

3-butyl-2-methyl-1H-pyridin-4-one Structure

3-butyl-2-methy...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-butyl-2-methyl-1H-pyridin-4-one Structure

3-butyl-2-methy...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-butyl-2-methyl-1H-pyridin-4-one Structure

3-butyl-2-methy...

benzyl 3-(hydroxy(phenyl)methyl)-2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

benzyl 3-(hydro...

~%

3-benzyl-2-methyl-1H-pyridin-4-one Structure

3-benzyl-2-meth...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-benzyl-2-methyl-1H-pyridin-4-one Structure

3-benzyl-2-meth...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-benzyl-2-methyl-1H-pyridin-4-one Structure

3-benzyl-2-meth...

4-Methoxypyridine Structure

4-Methoxypyridine

~%

3-[(2,6-difluorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2,6-difluor...

Benzyl 2-methyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate Structure

Benzyl 2-methyl...

~%

3-[(2,6-difluorophenyl)methyl]-2-methyl-1H-pyridin-4-one Structure

3-[(2,6-difluor...