A novel series of HIV-1 integrase inhibitors was synthesized and tested in both in vitro and ex vivo assays. These inhibitors are featured by the presence of a quinoline subunit and an ancillary aromatic ring linked by functionalized spacers such as amide, hydrazide, urea and 1-hydroxyprop-1-en-3-one moiety. Amide derivatives are the most promising ones and could serve as leads for further developments.
[Hodgson, Jonathan M.; Morton, Lincoln W.; Puddey, Ian B.; Beilin, Lawrence J.; Croft, Kevin D. Journal of Agricultural and Food Chemistry, 2000 , vol. 48, # 6 p. 2276 - 2280]
