QSAR modeling of synthesized 3-(1, 3-benzothiazol-2-yl) 2-phenyl quinazolin-4 (3H)-ones as potent antibacterial agents

P Sharma, A Kumar, P Kumari, J Singh…

Index: Sharma, Pratibha; Kumar, Ashok; Kumari, Prerna; Singh, Jitendra; Kaushik Medicinal Chemistry Research, 2012 , vol. 21, # 7 p. 1136 - 1148

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Citation Number: 9

Abstract

Abstract Present communication elicits the designing and synthesis of 3-(1, 3-benzothiazol-2- yl) 2-phenyl quinazolin-4 (3 H)-ones as potential antibacterial agents. A number of substituted 2-amino benzothiazoles, 2-amino-5-[(E)-phenyl diazenyl] benzoic acid, and 2- phenyl-4 H benzo [d][1, 3] oxazin-4-one were synthesized as the precursor substrates. The compounds were synthesized in excellent yields and the structures were corroborated on ...

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1-(2-Methylphenyl)thiourea Structure

614-78-8

1-(2-Methylphen...

~%

3-(4-methyl-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-65-1

3-(4-methyl-1,3...

4-Methylbenzo[d]thiazol-2-amine Structure

1477-42-5

4-Methylbenzo[d...

~%

3-(4-methyl-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-65-1

3-(4-methyl-1,3...

N/A Structure

1309261-84-4

N/A

~%

3-(4-methyl-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-65-1

3-(4-methyl-1,3...

Anthranilic acid Structure

118-92-3

Anthranilic acid

~%

3-(4-methyl-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-65-1

3-(4-methyl-1,3...

1-(2-Bromophenyl)thiourea Structure

5391-30-0

1-(2-Bromopheny...

~72%

2-AMINO-4-BROMOBENZOTHIAZOLE Structure

20358-02-5

2-AMINO-4-BROMO...

ammonium;thiocyanate Structure

1147550-11-5

ammonium;thiocyanate

|p|-Aminophenol hydrochloride Structure

51-78-5

|p|-Aminophenol...

~%

Thiourea,N-(2-hydroxyphenyl)- Structure

1520-26-9

Thiourea,N-(2-h...

2-Amino-6-bromobenzothiazole Structure

15864-32-1

2-Amino-6-bromo...

Bentranil Structure

1022-46-4

Bentranil

~81%

3-(6-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-67-3

3-(6-bromo-1,3-...

4-bromophenylthiourea Structure

2646-30-2

4-bromophenylth...

~%

3-(6-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-67-3

3-(6-bromo-1,3-...

4-Bromoaniline hydrochloride Structure

624-19-1

4-Bromoaniline ...

~%

3-(6-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-67-3

3-(6-bromo-1,3-...

2-Amino-6-bromobenzothiazole Structure

15864-32-1

2-Amino-6-bromo...

~%

3-(6-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-67-3

3-(6-bromo-1,3-...

N/A Structure

1309261-74-2

N/A

~%

3-(6-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-67-3

3-(6-bromo-1,3-...

Anthranilic acid Structure

118-92-3

Anthranilic acid

~%

3-(6-bromo-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-67-3

3-(6-bromo-1,3-...

Thiourea,N-(2-hydroxyphenyl)- Structure

1520-26-9

Thiourea,N-(2-h...

~67%

2-amino-1,3-benzothiazol-4-ol Structure

7471-03-6

2-amino-1,3-ben...

1-(2-Methoxyphenyl)thiourea Structure

1516-37-6

1-(2-Methoxyphe...

~70%

4-methoxy-1,3-benzothiazol-2-amine Structure

5464-79-9

4-methoxy-1,3-b...

m-Tolyl-thiourea Structure

621-40-9

m-Tolyl-thiourea

~66%

5-Methyl-1,3-benzothiazol-2-amine Structure

14779-17-0

5-Methyl-1,3-be...

m-Tolyl-thiourea Structure

621-40-9

m-Tolyl-thiourea

~61%

7-Methylbenzo[d]thiazol-2-amine Structure

14779-18-1

7-Methylbenzo[d...

m-Toluidine Hydrochloride Structure

638-03-9

m-Toluidine Hyd...

~%

7-Methylbenzo[d]thiazol-2-amine Structure

14779-18-1

7-Methylbenzo[d...

N-(3-Bromophenyl)thiourea Structure

21327-14-0

N-(3-Bromopheny...

~74%

7-Bromo-1,3-benzothiazol-2-amine Structure

20358-05-8

7-Bromo-1,3-ben...

o-anisidine hydrochloride Structure

134-29-2

o-anisidine hyd...

~%

3-(4-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-61-7

3-(4-methoxy-1,...

1-(2-Methoxyphenyl)thiourea Structure

1516-37-6

1-(2-Methoxyphe...

~%

3-(4-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-61-7

3-(4-methoxy-1,...

N/A Structure

1309261-83-3

N/A

~%

3-(4-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-61-7

3-(4-methoxy-1,...

4-methoxy-1,3-benzothiazol-2-amine Structure

5464-79-9

4-methoxy-1,3-b...

~%

3-(4-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-61-7

3-(4-methoxy-1,...

Anthranilic acid Structure

118-92-3

Anthranilic acid

~%

3-(4-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-61-7

3-(4-methoxy-1,...

m-Anisidine Hydrochloride Structure

27191-09-9

m-Anisidine Hyd...

~%

3-(5-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-63-9

3-(5-methoxy-1,...

1-(3-methoxyphenyl)-2-thiourea Structure

37014-08-7

1-(3-methoxyphe...

~%

3-(5-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-63-9

3-(5-methoxy-1,...

5-Methoxy-1,3-benzothiazol-2-amine Structure

54346-87-1

5-Methoxy-1,3-b...

~%

3-(5-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-63-9

3-(5-methoxy-1,...

6-amino-3-(5-methoxybenzo[d]thiazol-2-yl)-2-phenylquinazolin-4(3H)-one Structure

1309261-82-2

6-amino-3-(5-me...

~%

3-(5-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-63-9

3-(5-methoxy-1,...

Anthranilic acid Structure

118-92-3

Anthranilic acid

~%

3-(5-methoxy-1,3-benzothiazol-2-yl)-2-phenylquinazolin-4-one Structure

918154-63-9

3-(5-methoxy-1,...


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