e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Synlett

Design and synthesis of angucyclinone 5-aza analogues

JA Valderrama, MF González, P Colonelli, D Vásquez

Index: Valderrama, Jaime A.; Gonzalez, M. Florencia; Colonelli, Pamela; Vasquez, David Synlett, 2006 , # 17 p. 2777 - 2780

Full Text: HTML

Citation Number: 15

Abstract

Abstract A highly efficient one-pot procedure for the synthesis of phenanthridine-1, 7, 10- triones from acylbenzoquinones and cyclic enaminones is reported. The cycloaddition reactions of these quinones with 1-trimethylsilyloxybutadiene followed by hydrolysis and ...

2-Acetyl-1,4-benzoquinone Structure

2-Acetyl-1,4-be...

3-Amino-2-cyclohexenone Structure

3-Amino-2-cyclo...

~66%

10-hydroxy-6-methyl-2,3,4,5-tetrahydrophenanthridine-1,7-dione Structure

10-hydroxy-6-me...

10-hydroxy-2,3,4,5-tetrahydrophenanthridine-1,7-dione Structure

10-hydroxy-2,3,...

~68%

3,4-dihydro-2H-phenanthridine-1,7,10-trione Structure

3,4-dihydro-2H-...

3-Amino-2-cyclohexenone Structure

3-Amino-2-cyclo...

~%

8-hydroxy-3,4-dihydro-2H-benzo[j]phenanthridine-1,7,12-trione Structure

8-hydroxy-3,4-d...

8-(trimethylsilyloxy)-3,4,7a,8,11,11a-hexahydro-2H-benzo[j]phenanthridine-1,7,12-trione Structure

8-(trimethylsil...

~%

8-hydroxy-3,4-dihydro-2H-benzo[j]phenanthridine-1,7,12-trione Structure

8-hydroxy-3,4-d...

10-hydroxy-2,3,4,5-tetrahydrophenanthridine-1,7-dione Structure

10-hydroxy-2,3,...

~%

8-hydroxy-3,4-dihydro-2H-benzo[j]phenanthridine-1,7,12-trione Structure

8-hydroxy-3,4-d...

3,4-dihydro-2H-phenanthridine-1,7,10-trione Structure

3,4-dihydro-2H-...

~%

8-hydroxy-3,4-dihydro-2H-benzo[j]phenanthridine-1,7,12-trione Structure

8-hydroxy-3,4-d...

10-hydroxy-6-methyl-2,3,4,5-tetrahydrophenanthridine-1,7-dione Structure

10-hydroxy-6-me...

~64%

6-methyl-3,4-dihydro-2H-phenanthridine-1,7,10-trione Structure

6-methyl-3,4-di...

2,5-Dihydroxybenzaldehyde Structure

2,5-Dihydroxybe...

5,5-Dimethyl-3-aminocyclohex-2-enone Structure

5,5-Dimethyl-3-...

~80%

3,3-dimethyl-2,4-dihydrophenanthridine-1,7,10-trione Structure

3,3-dimethyl-2,...

5,5-Dimethyl-3-aminocyclohex-2-enone Structure

5,5-Dimethyl-3-...

2,5-Dihydroxyacetophenone Structure

2,5-Dihydroxyac...

~65%

3,3,6-trimethyl-2,4-dihydrophenanthridine-1,7,10-trione Structure

3,3,6-trimethyl...

3,6-dioxocyclohexa-1,4-diene-1-carbaldehyde Structure

3,6-dioxocycloh...

3-Amino-2-cyclohexenone Structure

3-Amino-2-cyclo...

~86%

10-hydroxy-2,3,4,5-tetrahydrophenanthridine-1,7-dione Structure

10-hydroxy-2,3,...