Combining aspects of the platinum anticancer drugs picoplatin and BBR3464 to synthesize a new family of sterically hindered dinuclear complexes; their synthesis, …

…, KD Trotter, OB Sutcliffe, JA Plumb, B Waddell…

Index: Brown, Sarah D.; Trotter, Katherine D.; Sutcliffe, Oliver B.; Plumb, Jane A.; Waddell, Bruce; Briggs, Naomi E. B.; Wheate, Nial J. Dalton Transactions, 2012 , vol. 41, # 37 p. 11330 - 11339

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Citation Number: 21

Abstract

Picoplatin is a sterically hindered mononuclear platinum drug undergoing clinical trials. The 2-methylpyridine ring provides steric hindrance to the drug, preventing attack from biological nucleophiles. BBR3464 is a trinuclear platinum drug which was recently in Phase II clinical trials, and is highly cytotoxic both in vitro and in vivo; it derives this activity through the flexible adducts it forms with DNA. In this work we sought to combine the properties of both ...