Synthesis of selective butyrylcholinesterase inhibitors coupled between α-lipoic acid and polyphenols by using 2-(piperazin-1-yl) ethanol linker

GH Yeun, SH Lee, YB Lim, HS Lee…

Index: Yeun, Go Heum; Lee, Seung Hwan; Lim, Yong Bae; Lee, Hye Sook; Won, Moo-Ho; Lee, Bong Ho; Park, Jeong Ho Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1025 - 1029

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Citation Number: 6

Abstract

Abstract In the previous paper (Bull. Korean Chem. Soc., 2011, 32, 2997), the hybrid molecules between-lipoic acid (ALA) and polyphenols (PPs) connected with neutral 2-(2- aminoethoxy) ethanol linker (linker-1) showed new biological activity such as butyrylcholinesterase (BuChE) inhibition. In order to increase the binding affinity of the hybrid compounds to cholinesterase (ChE), the neutral 2-(2-aminoethoxy) ethanol (linker ...