e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Synthesis of selective butyrylcholinesterase inhibitors coupled between α-lipoic acid and polyphenols by using 2-(piperazin-1-yl) ethanol linker
GH Yeun, SH Lee, YB Lim, HS Lee…
Index: Yeun, Go Heum; Lee, Seung Hwan; Lim, Yong Bae; Lee, Hye Sook; Won, Moo-Ho; Lee, Bong Ho; Park, Jeong Ho Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1025 - 1029
Abstract In the previous paper (Bull. Korean Chem. Soc., 2011, 32, 2997), the hybrid molecules between-lipoic acid (ALA) and polyphenols (PPs) connected with neutral 2-(2- aminoethoxy) ethanol linker (linker-1) showed new biological activity such as butyrylcholinesterase (BuChE) inhibition. In order to increase the binding affinity of the hybrid compounds to cholinesterase (ChE), the neutral 2-(2-aminoethoxy) ethanol (linker ...