Potent inhibitors of phosphatidylinositol 3 (PI3) kinase that have antiproliferative activity only when delivered as prodrug forms

NJ O'Brien, S Amran, J Medan, B Cleary…

Index: O'Brien, Nathan J.; Amran, Syazwani; Medan, Jelena; Cleary, Ben; Deady, Leslie W.; Jennings, Ian G.; Thompson, Philip E.; Abbott, Belinda M. ChemMedChem, 2013 , vol. 8, # 6 p. 914 - 918

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Citation Number: 3

Abstract

Phosphatidylinositol 3 kinase (PI3K) enzymes have emerged as important therapeutic targets in recent years as PI3K isoforms are involved in numerous cell signaling pathways associated with a range of diseases.[1] Prominent among these is cancer, with numerous instances of genetic mutations that enhance the PI3K signal identified, such as mutations in the PI3KCA gene that expresses PI3Ka, and downregulation of phosphatase PTEN that ...