Oxytocin Analogues Containing No Disulfide Bond. I. Synthesis of the Lactam of L-Tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-L-α-aminosuberyl-L-prolyl-L- …

A Kobayashi, S Hase, R Kiyoi…

Index: Kobayashi,A. et al. Bulletin of the Chemical Society of Japan, 1969 , vol. 42, # 12 p. 3491 - 3495

Full Text: HTML

Citation Number: 10

Abstract

The synthesis of an analogue of deamino-oxytocin, which has an ethylene linkage in place of the disulfide bond, was studied in order to establish a general route for the synthesis of such cyclic peptides. L-α-Aminosuberic acid (Asu) was converted to the N- benzyloxycarbonyl-ω-t-butyl ester and was used as the starting substance for the synthesis. A protected octapeptide was prepared by the step-by-step elongation method with the ...