Synthesis, structure-activity relationships, and antitumor studies of 2-benzoxazolyl hydrazones derived from alpha-(N)-acyl heteroaromatics

…, G Pürstinger, KS Thies, G Heinisch…

Index: Easmon, Johnny; Puerstinger, Gerhard; Thies, Katrin-Sofia; Heinisch, Gottfried; Hofmann, Johann Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6343 - 6350

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Citation Number: 121

Abstract

Recently we have described the antitumor activities of 2-benzoxazolylhydrazones derived from 2-formyl and 2-acetylpyridines. In search of a more efficacious analogue, compounds in which the 2-acetylpyridine moiety has been replaced by 2-acylpyridine and α-(N)- acetyldiazine/quinoline groups have been synthesized. The 2-acylpyridyl hydrazones inhibited in vitro cell proliferation in the nM range, whereas the hydrazones derived from ...