Total synthesis and bioactivity of some naturally occurring pterulones

BWT Gruijters, A van Veldhuizen…

Index: Gruijters, Bas W. T.; Van Veldhuizen, Albertus; Weijers, Carel A. G. M.; Wijnberg, Joannes B. P. A. Journal of Natural Products, 2002 , vol. 65, # 4 p. 558 - 561

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Citation Number: 16

Abstract

The naturally occurring pterulones 1, 3, and 13 were synthesized in high overall yield from readily available methyl 3-(2-propenyl)-4-(2-propenyloxy) benzoate (6) by employing ring- closing metathesis (RCM) as a key step. The biological activities of the synthesized pterulones were tested using cells of Rhodotorula glutinis and Saccharomyces cerevisiae.