An extremely powerful acylation reaction of alcohols with acid anhydrides catalyzed by trimethylsilyl trifluoromethanesulfonate

PA Procopiou, SPD Baugh, SS Flack…

Index: Procopiou, Panayiotis A.; Baugh, Simon P.D.; Flack, Stephen S.; Inglis, Graham G.A. Journal of Organic Chemistry, 1998 , vol. 63, # 7 p. 2342 - 2347

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Citation Number: 246

Abstract

Trimethylsilyl trifluoromethanesulfonate is an excellent catalyst for the acylation of alcohols with acid anhydrides. Highly functionalized primary, secondary, tertiary, and allylic alcohols, and phenols, were acylated cleanly and efficiently and in a fraction of the time used under the standard DMAP conditions.