Organic letters

Ligand-Promoted, Boron-Mediated Chemoselective Carboxylic Acid Aldol Reaction

H Nagai, Y Morita, Y Shimizu, M Kanai

Index: Downey, C. Wade; Johnson, Miles W.; Lawrence, Daniel H.; Fleisher, Alan S.; Tracy, Kathryn J. Journal of Organic Chemistry, 2010 , vol. 75, # 15 p. 5351 - 5354

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Abstract

... C 6 H 5 CF 3 (1.0 mL) was used as solvent ... Condition B was essential for reactions with aliphatic aldehydes (1b, 1i, 1j, and 1k ... Diastereomeric ratio was determined by 1 H NMR analysis of crude mixture of 3. Isolated yield was determined after conversion of the aldol products into ...