Cinnamaldehyde

Modify Date: 2024-01-01 22:01:17

Cinnamaldehyde structure	Common Name	Cinnamaldehyde
	CAS Number	104-55-2	Molecular Weight	132.159
	Density	1.0±0.1 g/cm3	Boiling Point	246.8±9.0 °C at 760 mmHg
	Molecular Formula	C₉H₈O	Melting Point	-7.5ºC
	MSDS	Chinese USA	Flash Point	71.1±0.0 °C
	Symbol	GHS07	Signal Word	Warning

Use of Cinnamaldehyde

Cinnamaldehyde is a major and a bioactive compound isolated from the leaves of Cinnamomum osmophloeum kaneh. Cinnamaldehyde is a cytokine production inhibitor. Cinnamaldehyde has anti-bacteria, anti-oxidation, and anti-inflammatory properties[1].

Name	Cinnamaldehyde
Synonym	More Synonyms

Description	Cinnamaldehyde is a major and a bioactive compound isolated from the leaves of Cinnamomum osmophloeum kaneh. Cinnamaldehyde is a cytokine production inhibitor. Cinnamaldehyde has anti-bacteria, anti-oxidation, and anti-inflammatory properties[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Inflammation/Immunology Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Cinnamaldehyde inhibits ROS release and the activation of MAPKs as well as pro-inflammatory cytokines expression within TLRs activated cultured monocytes/macrophages[1] .Cinnamaldehyde induces apoptosis by mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells, and induces apoptosis in human hepatoma cells through activation of the proapoptotic Bcl-2 family proteins[1].
References	[1]. Chao LK, et al. Cinnamaldehyde inhibits pro-inflammatory cytokines secretion from monocytes/macrophages through suppression of intracellular signaling. Food Chem Toxicol. 2008;46(1):220‐231.

Density	1.0±0.1 g/cm3
Boiling Point	246.8±9.0 °C at 760 mmHg
Melting Point	-7.5ºC
Molecular Formula	C₉H₈O
Molecular Weight	132.159
Flash Point	71.1±0.0 °C
Exact Mass	132.057510
PSA	17.07000
LogP	2.12
Vapour density	4.6 (vs air)
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.577
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong bases.
Water Solubility	Slightly soluble

Cinnamaldehyde MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD6475000

CHEMICAL NAME :: Cinnamaldehyde

CAS REGISTRY NUMBER :: 104-55-2

BEILSTEIN REFERENCE NO. :: 0605737

LAST UPDATED :: 199710

DATA ITEMS CITED :: 25

MOLECULAR FORMULA :: C9-H8-O

MOLECULAR WEIGHT :: 132.17

WISWESSER LINE NOTATION :: VH1U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2220 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2225 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1160 mg/kg

TOXIC EFFECTS :: Behavioral - coma

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg/24W-C

TOXIC EFFECTS :: Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8092 mg/kg/17W-I

TOXIC EFFECTS :: Liver - liver function tests impaired

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 55 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 275 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 15 mg/L

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** TOXICOLOGY REVIEW DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 1(5),5,1981 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83182 No. of Facilities: 372 (estimated) No. of Industries: 14 No. of Occupations: 38 No. of Employees: 13984 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83182 No. of Facilities: 6159 (estimated) No. of Industries: 58 No. of Occupations: 76 No. of Employees: 111108 (estimated) No. of Female Employees: 43381 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H317-H319-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	GD6476000
Packaging Group	I; II; III
Hazard Class	6.1
HS Code	2912299000

Precursor 9
CAS#:37973-54-9 1,1-diacetoxy-3... CAS#:104-54-1 Cinnamyl alcohol CAS#:104-53-0 3-Phenylpropanal CAS#:7318-33-4 p-Toluenesulfon...
CAS#:4187-87-5 1-Phenyl-2-prop... CAS#:4364-06-1 cinnamaldehyde ... CAS#:4360-47-8 Cinnamonitrile CAS#:26958-41-8 2-(2-phenylethe...
CAS#:591-50-4 Iodobenzene
DownStream 9
CAS#:100037-80-7 6-phenylthieno[... CAS#:10264-23-0 Benzenepropanam... CAS#:110611-22-8 (3R)-1-phenylpe... CAS#:106549-54-6 3-methylidene-5...
CAS#:5443-49-2 α-Bromocinnamal... CAS#:103-82-2 Phenylacetic acid CAS#:100-52-7 Benzaldehyde CAS#:14171-89-2 6-Phenyl-2-hexanone
CAS#:1456-19-5 1H-Benzimidazol...

HS Code	2912190090
Summary	2912190090 acyclic aldehydes without other oxygen function。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

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Influences of Ulva fasciata polysaccharide on the rheology and stabilization of cinnamaldehyde emulsions.

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(E)-3-phenylprop-2-enal

trans-Cinnamic Aldehyde

(2E)-3-Phenyl-2-propenal

Cinnamaldehyde, (E)-

trans-Cinnamylaldehyde

2-Propenal, 3-phenyl-, (2E)-

β-phenylacrolein

Cinnamic aldehyde

(2E)-3-phenylprop-2-enal

(E)-3-phenylpropenal

cinnamic aldehyde, (E)-isomer

Cinnamyl aldehyde

(E)-3-Phenyl-propenal

2-Propenal, 3-phenyl-, (E)- (9CI)

trans-3-Phenylacrolein

3-Phenylacrolein

trans-Phenylacrolein

Acrolein, 3-phenyl-

(2E)-3-Phenylacrylaldehyde

MFCD00007000

4-07-00-00984 (Beilstein Handbook Reference)

trans-Cinnamaldehyde

(E)-cinnamaldehyde

EINECS 203-213-9

Cinnamaldehyde, trans-

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Cinnamaldehyde

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