Since the Grignard reagent was discovered in 1900, it has been widely used for the construction of organic molecules. It is the most basic and indispensable tool for organic chemists. 1 Grignard reagents have some common reaction patterns: (1) nucleophilic addition or substitution, (2) proton abstraction as a base, (3) magnesium−halogen exchange reactions. 2 There have been reports of some radical reactions using Grignard reagents in the presence or absence of a ...
