Novel 1-phenyl-3-hydroxy-4-pyridinone derivatives as Multifunctional Agents for the therapy of Alzheimer's Disease

R Sheng, L Tang, L Jiang, L Hong, Y Shi…

Index: Green, David E.; Bowen, Meryn L.; Scott, Lauren E.; Storr, Tim; Merkel, Michael; Boehmerle, Karin; Thompson, Katherine H.; Patrick, Brian O.; Schugar, Harvey J.; Orvig, Chris Dalton Transactions, 2010 , vol. 39, # 6 p. 1604 - 1615

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Abstract

... 1a–d with para- or meta-aminophenol under microwave irradiation provided compounds 2a–e, followed by ... a Reaction conditions: (a) 4-aminophenol or 3-aminophenol, 0.38 mol/L HCl solution, EtOH ... 1 R 2 , triethylamine, CH 3 CN, reflux, yield 68–82%; (d) 10% Pd/C, H 2 , CH 3 ...