Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives

A Fassihi, D Abedi, L Saghaie, R Sabet, H Fazeli…

Index: Fassihi, Afshin; Abedi, Daryoush; Saghaie, Lotfollah; Sabet, Razieh; Fazeli, Hossein; Bostaki, Ghasem; Deilami, Omid; Sadinpour, Hekmatollah European Journal of Medicinal Chemistry, 2009 , vol. 44, # 5 p. 2145 - 2157

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Citation Number: 46

Abstract

A series of Mannich bases of 2-alkyl-3-hydroxy-pyridine-4-ones, namely 2-alkyl-3-hydroxy-5- N-piperidylmethyl or N, N-dialkylaminomethyl pyridine-4-ones 9, 10 and 15–18, two derivatives of N-aryl-2-methyl-3-hydroxy-pyridine-4-ones 19, 20 and two N-alkyl derivatives of maltol, 21 and 22 were prepared. They were screened for their antibacterial and antifungal activities against a variety of microorganisms using micro plate Alamar Blue® ...