Organic letters

Dramatic rate acceleration of the Baylis-Hillman reaction in homogeneous medium in the presence of water

J Cai, Z Zhou, G Zhao, C Tang

Index: Cai, Juexiao; Zhou, Zhenghong; Zhao, Guofeng; Tang, Chuchi Organic Letters, 2002 , vol. 4, # 26 p. 4723 - 4725

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Citation Number: 184

Abstract

In homogeneous H2O/solvent medium, the reaction rate of aromatic aldehydes and acrylonitrile or acrylate was greatly accelerated, which led to shorter reaction time, lower reaction temperature, and higher yield. In this reaction, Me3N, DMAP, DABCO, and urotropine were good catalysts. Except for low-carbon alcohols, tetrahydrofuran, 1, 4- dioxane, and acetonitrile could be chosen as the solvent. Under this condition, the ...