Molecules

Efficient preparation of α-ketoacetals

…, C Barrera-Mendoza, HA Jiménez-Vázquez…

Index: Ayala-Mata, Francisco; Barrera-Mendoza, Citlalli; Jimenez-Vazquez, Hugo A.; Vargas-Diaz, Elena; Zepeda, L. Gerardo Molecules, 2012 , vol. 17, # 12 p. 13864 - 13878

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Citation Number: 2

Abstract

Abstract: The Weinreb amides 2a, b were prepared from the α, α-dimethoxyacetic acids 1c, d. A number of representative nucleophilic additions (RMgX and RLi) on 2 afforded α- ketoacetals 3a–j in 70–99% yield. These compounds represent a versatile arrangement of functional groups of significant synthetic value, as demonstrated in the synthesis of (±)- salbutamol.