Synthesis of Pteroic and Pteroylglutamic Acids. 1 II.

DI Weisblat, BJ Magerlein, DR Myers…

Index: Weisblat et al. Journal of the American Chemical Society, 1953 , vol. 75, p. 5893,5895

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Citation Number: 15

Abstract

A new synthesis of pteroylglutamic acid is described in which diethyl N-tosyl-p- aminobenzoyl-L-glutamate is alkylated with 2, 3-oxidopropionaldehyde diethyl acetal, the product oxidized and condensed with 2, 4, 5-triamin0-6. hydroxypyrimidine. Detosylation of this product with hydrogen bromide in acetic acid in the presence of phenol gives the final product in good yield.