Triazolbenzo [d] thiazoles: Efficient synthesis and biological evaluation as neuroprotective agents

B Avila, A Roth, H Streets, DS Dwyer…

Index: Avila, Belem; Roth, Aaron; Streets, Heather; Kurth, Mark J.; Dwyer, Donard S. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 18 p. 5976 - 5978,3

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Citation Number: 2

Abstract

A number of (1H-1, 2, 3-triazol-1-yl) benzo [d] thiazoles were synthesized utilizing a versatile Cu-catalyzed azide–alkyne click reaction (CuAAC) on tautomeric benzo [4, 5] thiazolo [3, 2- d] tetrazole (1) and 2-azidobenzo [d] thiazole (2) starting materials. Moreover, one of the resulting products of this investigation, triazolbenzo [d] thiazole 22, was found to possess significant neuroprotective activity in human neuroblastoma (SH-SY5Y) cells.