Synthetic communications

Generalized Method for the Production of 1, 3??Benzoxazine, 1, 3??Benzothiazine, and Quinazoline Derivatives from 2??(Hydroxy, Thio, or Amino) Aromatic Acids Using …

KM Pritchard, JM Al??Rawi, AB Hughes

Index: Pritchard, Kaylene M.; Al-Rawi, Jasim M.; Hughes, Andrew B. Synthetic Communications, 2005 , vol. 35, # 12 p. 1601 - 1611

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Citation Number: 19

Abstract

Abstract A modified one??pot method was developed for the synthesis of 1, 3??benzoxazines, in which the preparation of unstable thiocyanogen was omitted. The method was found to be general for substituted (methyl, methoxy, halo, and hydroxy) 2??hydroxy benzoic acids and 2?? hydroxy naphthoic acids. The method was extended to 2??thio, 2??amino, and N??methyl aminobenzoic acid with which the synthesis of 1, 3??benzothiazine and quinazoline ...