Tetrahedron letters

Palladium-catalyzed amination of aryl dibromides with secondary amines: synthetic and mechanistic aspects

IP Beletskaya, AG Bessmertnykh, R Guilard

Index: Beletskaya, Irina P.; Bessmertnykh, Alla G.; Guilard, Roger Tetrahedron Letters, 1999 , vol. 40, # 35 p. 6393 - 6397

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Citation Number: 39

Abstract

Diaminobenzenes are obtained starting from m-and p-dibromobenzenes and secondary amines in the presence of Pd (dba) 2/P (o-tolyl) 3and sodium tert-butoxide in moderate to good yields. Reductive dehalogenation of aryl dibromides is a major side reaction under these conditions. The study of this reaction has shown that the formation of reductive dehalogenation products occurs according to two independent ways. The first one ...