5-Fluoro-2-methyl-N-[4-(5 H-pyrrolo [2, 1-c]-[1, 4] benzodiazepin-10 (11 H)-ylcarbonyl)-3-chlorophenyl] benzamide (VPA-985): An Orally Active Arginine Vasopressin …

…, PS Chan, X Ru, H Mazandarani, T Bailey

Index: Albright, J. Donald; Reich, Marvin F.; Delos Santos, Efren G.; Dusza, John P.; Sum, Fuk-Wah; Venkatesan, Aranapakam M.; Coupet, Joseph; Chan, Peter S.; Ru, Xun; Mazandarani, Hossein; Bailey, Trina Journal of Medicinal Chemistry, 1998 , vol. 41, # 14 p. 2442 - 2444

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Citation Number: 125

Abstract

Arginine vasopressin (AVP) is released from the posterior pituitary, in response to either increased plasma osmolality detected by brain osmoreceptors or decreased blood volume and blood pressure sensed by low-pressure volume receptors and arterial baroreceptors. The hormone exerts its actions through three welldefined receptor subtypes: vascular V1a, hormonereleasing V1b (V3), and renal V2 receptors. 1-3 Both V1a and V2 receptors are ...