The Journal of Organic Chemistry

A short synthesis of two chiral anthracycline AB synthons

HL Holland, P Viski

Index: Holland, Herbert L.; Viski, Peter Journal of Organic Chemistry, 1991 , vol. 56, # 17 p. 5226 - 5229

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Citation Number: 9

Abstract

An alternative approach to the asymmetric synthesis of anthracyclines has been to construct an AB synthon such as 7 or 11 that possesses all the necessary chirality. Molecules of this type are currently only available by lengthy procedures involving a chiral precursor such as a carbohydrateg or via resolution of a synthetic intermediate. 1 We now report a short and efficient synthesis of chiral anthracycline AB synthons both with (7) and without (5) the ...