Synthesis and biological studies of silver N-heterocyclic carbene complexes derived from 4, 5-diarylimidazole

…, A Hagenbach, U Abram, B Niu, A Mariappan…

Index: Liu, Wukun; Bensdorf, Kerstin; Hagenbach, Adelheid; Abram, Ulrich; Niu, Ben; Mariappan, Aruljothi; Gust, Ronald European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5927 - 5934

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Citation Number: 31

Abstract

A novel class of silver N-heterocyclic carbene complexes (5a–f) were synthesized in high yield by reacting silver (I) oxide with 4, 5-diarylimidazolium halides (4a–f). The complexes were characterized using NMR and IR spectroscopy. The structure was confirmed on the example of bromo [1, 3-diethyl-4, 5-bis (4-fluorophenyl) imidazol-2-ylidene] silver (I)(5c) by crystal structure analysis. The X-ray structure indicated a three-dimensional coordination ...