Lennoxamine () and chilenamine () have been synthesized from 3-(3, 4- methylenedioxybenzylidene)-6, 7-dimethoxyphthalide () in four and five high-yielding steps, respectively. The key step of the process is the cyclization, by intramolecular alkylation, of 3- (3, 4-methylenedioxybenzyl)-6, 7-dimethoxyphthalimidin-2-ylacet
[Roscini, Claudio; Davies, David M. E.; Berry, Malcolm; Orr-Ewing, Andrew J.; Booker-Milburn, Kevin I. Angewandte Chemie - International Edition, 2008 , vol. 47, # 12 p. 2283 - 2286]
