Cinnamic acid derived oxazolinium ions as novel cytotoxic agents

L Hedvati, A Nudelman, E Falb, B Kraiz, R Zhuk…

Index: Hedvati, Lilach; Nudelman, Abraham; Falb, Eliezer; Kraiz, Boris; Zhuk, Regina; Sprecher, Milon European journal of medicinal chemistry, 2002 , vol. 37, # 7 p. 607 - 616

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Citation Number: 9

Abstract

Substituted cinnamoyl chlorides, 11, were converted into (2-hydroxyethyl)-oxazolinium chlorides 14, N, N-bis-(2-chloroethyl) amides 16 and (2-chloroethyl)-oxazolinium chlorides 17. Although derivatives 14 which possess electron-donating substituents (Me or MeO) were more potent than those substituted by electron-withdrawing groups (NO2, Cl or CF3), the difference in cytotoxic actin was not significant. Modification of the lipophilic character in a ...